Benutzer: Gast  Login
Titel:

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies-the German Cancer Consortium approach

Dokumenttyp:
Review
Autor(en):
Krackhardt, Angela M.; Anliker, Brigitte; Hildebrandt, Martin; Bachmann, Michael; Eichmueller, Stefan B.; Nettelbeck, Dirk M.; Renner, Matthias; Uharek, Lutz; Willimsky, Gerald; Schmitt, Michael; Wels, Winfried S.; Schuessler-Lenz, Martina
Abstract:
Adoptive transfer of T cells genetically modified by TCRs or CARs represents a highly attractive novel therapeutic strategy to treat malignant diseases. Various approaches for the development of such gene therapy medicinal products (GTMPs) have been initiated by scientists in recent years. To date, however, the number of clinical trials commenced in Germany and Europe is still low. Several hurdles may contribute to the delay in clinical translation of these therapeutic innovations including the...     »
Zeitschriftentitel:
Cancer Immunol Immunother
Jahr:
2018
Band / Volume:
67
Heft / Issue:
4
Seitenangaben Beitrag:
513-523
Volltext / DOI:
doi:10.1007/s00262-018-2119-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29380009
Print-ISSN:
0340-7004
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Kliniken und Institute
 BibTeX