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Titel:

Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.

Dokumenttyp:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Article
Autor(en):
Tong, J; D'Alessio, D; Ramisch, J; Davis, HW; Stambrook, E; Tschöp, MH; Bidlingmaier, M
Abstract:
The 20-kDa human GH (hGH) is produced in the pituitary by alternative splicing of the hGH-N gene. The 20-kDa hGH promotes growth similarly to 22-kDa or total hGH, the predominant form in circulation, but the relative effects of these isoforms on glucose metabolism have been debated.To investigate the effect of ghrelin on 20-kDa and total hGH secretion in healthy, nonobese subjects. We also studied associations between basal GH concentration and fasting glucose and insulin as well as between dyna...     »
Zeitschriftentitel:
J Clin Endocrinol Metab
Jahr:
2012
Band / Volume:
97
Heft / Issue:
9
Seitenangaben Beitrag:
3366-74
Volltext / DOI:
doi:10.1210/jc.2012-2012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22745239
Print-ISSN:
0021-972X
TUM Einrichtung:
Kliniken und Institute
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