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Title:

A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Klapproth, Sarah; Bromberger, Thomas; Türk, Clara; Krüger, Marcus; Moser, Markus
Abstract:
Binding of kindlins to integrins is required for integrin activation, stable ligand binding, and subsequent intracellular signaling. How hematopoietic kindlin-3 contributes to the assembly and stability of the adhesion complex is not known. Here we report that kindlin-3 recruits leupaxin into podosomes and thereby regulates paxillin phosphorylation and podosome turnover. We demonstrate that the activity of the protein tyrosine phosphatase PTP-PEST, which controls paxillin phosphorylation, requir...     »
Journal title abbreviation:
J Cell Biol
Year:
2019
Journal volume:
218
Journal issue:
10
Pages contribution:
3436-3454
Fulltext / DOI:
doi:10.1083/jcb.201903109
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31537712
Print-ISSN:
0021-9525
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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