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Title:

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tan, Likai; Sandrock, Inga; Odak, Ivan; Aizenbud, Yuval; Wilharm, Anneke; Barros-Martins, Joana; Tabib, Yaara; Borchers, Alina; Amado, Tiago; Gangoda, Lahiru; Herold, Marco J; Schmidt-Supprian, Marc; Kisielow, Jan; Silva-Santos, Bruno; Koenecke, Christian; Hovav, Avi-Hai; Krebs, Christian; Prinz, Immo; Ravens, Sarina
Abstract:
IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understood. Here, single-cell RNA-seq profiling identifies IL-17-producing Vγ6+ T cells as a highly homogeneous Scart1+ population in contrast to their Scart2+ IL-17-producing Vγ4+ T cell counterparts. Parabi...     »
Journal title abbreviation:
Cell Rep
Year:
2019
Journal volume:
27
Journal issue:
12
Pages contribution:
3657-3671.e4
Fulltext / DOI:
doi:10.1016/j.celrep.2019.05.064
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31216482
Print-ISSN:
2211-1247
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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