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Title:

Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Bromberger, Thomas; Zhu, Liang; Klapproth, Sarah; Qin, Jun; Moser, Markus
Abstract:
Recruitment and tethering of talin to the plasma membrane initiate the process of integrin activation. Multiple factors including the Rap1 proteins, RIAM (also known as APBB1IP) and PIP2 bind talin proteins and have been proposed to regulate these processes, but not systematically analyzed. By expressing specific talin mutants into talin-null fibroblasts, we show that binding of the talin F0 domain to Rap1 synergizes with membrane lipid binding of the talin F2 domain during talin membrane target...     »
Journal title abbreviation:
J Cell Sci
Year:
2019
Journal volume:
132
Journal issue:
21
Fulltext / DOI:
doi:10.1242/jcs.235531
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31578239
Print-ISSN:
0021-9533
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
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