Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Klapproth, Sarah; Bromberger, Thomas; Türk, Clara; Krüger, Marcus; Moser, Markus
Abstract:
Binding of kindlins to integrins is required for integrin activation, stable ligand binding, and subsequent intracellular signaling. How hematopoietic kindlin-3 contributes to the assembly and stability of the adhesion complex is not known. Here we report that kindlin-3 recruits leupaxin into podosomes and thereby regulates paxillin phosphorylation and podosome turnover. We demonstrate that the activity of the protein tyrosine phosphatase PTP-PEST, which controls paxillin phosphorylation, requir...     »
Zeitschriftentitel:
J Cell Biol
Jahr:
2019
Band / Volume:
218
Heft / Issue:
10
Seitenangaben Beitrag:
3436-3454
Volltext / DOI:
doi:10.1083/jcb.201903109
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31537712
Print-ISSN:
0021-9525
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
 BibTeX