Benutzer: Gast  Login
Titel:

The Unsolved Puzzle of c-Rel in B Cell Lymphoma.

Dokumenttyp:
Journal Article; Review
Autor(en):
Kober-Hasslacher, Maike; Schmidt-Supprian, Marc
Abstract:
Aberrant constitutive activation of Rel/NF-κB transcription factors is a hallmark of numerous cancers. Of the five Rel family members, c-Rel has the strongest direct links to tumorigenesis. c-Rel is the only member that can malignantly transform lymphoid cells in vitro. Furthermore, c-Rel is implicated in human B cell lymphoma through the frequent occurrence of REL gene locus gains and amplifications. In normal physiology, high c-Rel expression predominates in the hematopoietic lineage and a div...     »
Zeitschriftentitel:
Cancers (Basel)
Jahr:
2019
Band / Volume:
11
Heft / Issue:
7
Volltext / DOI:
doi:10.3390/cancers11070941
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31277480
TUM Einrichtung:
Experimentelle Hämatologie (Prof. Schmidt-Supprian)
 BibTeX