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Titel:

PiggyBac Transposon-Based Insertional Mutagenesis in Mice.

Dokumenttyp:
Journal Article
Autor(en):
Friedrich, Mathias J; Bronner, Iraad F; Liu, Pentao; Bradley, Allan; Rad, Roland
Abstract:
While sequencing and array-based studies are creating catalogues of genetic alterations in cancer, discriminating cancer drivers among the large sets of epigenetically, transcriptionally or posttranslationally dysregulated genes remains a challenge. Transposon-based genetic screening in mice has proven to be a powerful approach to address this challenge. Insertional mutagenesis directly flags biologically relevant genes and, combined with the transposon's unique molecular fingerprint, facilitate...     »
Zeitschriftentitel:
Methods Mol Biol
Jahr:
2019
Band / Volume:
1907
Seitenangaben Beitrag:
171-183
Volltext / DOI:
doi:10.1007/978-1-4939-8967-6_14
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30543000
Print-ISSN:
1064-3745
TUM Einrichtung:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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