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Title:

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rosenbaum, Marc; Gewies, Andreas; Pechloff, Konstanze; Heuser, Christoph; Engleitner, Thomas; Gehring, Torben; Hartjes, Lara; Krebs, Sabrina; Krappmann, Daniel; Kriegsmann, Mark; Weichert, Wilko; Rad, Roland; Kurts, Christian; Ruland, Jürgen
Abstract:
Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling mechanisms that mediate these effects remain ill-defined. Here we show that CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-κB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can b...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-10203-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31138793
Print-ISSN:
2041-1723
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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