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Title:

DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Noreen, Faiza; Küng, Taya; Tornillo, Luigi; Parker, Hannah; Silva, Miguel; Weis, Stefan; Marra, Giancarlo; Rad, Roland; Truninger, Kaspar; Schär, Primo
Abstract:
BACKGROUND: Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to understand underlying mechanisms and functions. METHODS: We have assessed genome-wide DNA methylation in the healthy normal colon mucosa (HNM), precursor lesions and CCs in a first comprehensive study to de...     »
Journal title abbreviation:
Clin Epigenetics
Year:
2019
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13148-019-0791-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31842975
Print-ISSN:
1868-7075
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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