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Titel:

Engineering CRISPR mouse models of cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Weber, Julia; Rad, Roland
Abstract:
Gene targeting in mammals has revolutionized the study of complex diseases, involving the interaction of multiple genes, cells, and organ systems. In cancer, genetically engineered mouse models deciphered biological principles by integrating molecular mechanisms, cellular processes, and environmental signals. Major advances in manipulative mouse genetics are currently emerging from breakthroughs in gene editing, which open new avenues for rapid model generation. Here, we review recent developmen...     »
Zeitschriftentitel:
Curr Opin Genet Dev
Jahr:
2019
Band / Volume:
54
Seitenangaben Beitrag:
88-96
Volltext / DOI:
doi:10.1016/j.gde.2019.04.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31078083
Print-ISSN:
0959-437X
TUM Einrichtung:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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