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Title:

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Document type:
Journal Article
Author(s):
Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; Lepennetier, Gildas; Engleitner, Thomas; Garg, Garima; Muschaweckh, Andreas; Mitsdörffer, Meike; Koedel, Uwe; Höchst, Bastian; Knolle, Percy; Gunzer, Matthias; Hemmer, Bernhard; Rad, Roland; Merkler, Doron; Korn, Thomas
Abstract:
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G+ cells were recruited to the CNS during experimental autoimmune encephalomyelitis (EAE), interacted with B cells that produced the cytokines GM-CSF and interleukin-6 (IL-6), and acquired properties of PMN-MDSCs in the CNS in a manner dependent on the signal transdu...     »
Journal title abbreviation:
Nat Immunol
Year:
2018
Journal volume:
19
Journal issue:
12
Pages contribution:
1341-1351
Fulltext / DOI:
doi:10.1038/s41590-018-0237-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30374128
Print-ISSN:
1529-2908
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik; Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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