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Title:

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, M S; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D; Dudek, Monika; Robson, Samuel C; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A; Ponstingl, Hannes; Dias, Joao M L; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew J; Rad, Roland; Prinjha, Rab K; Marioni, John C; Huntly, Brian; Batson, Jennife...     »
Abstract:
We recently identified the splicing kinase gene SRPK1 as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell differentiation and prolonged survival of mice transplanted with MLL-rearranged AML. RNA-seq analysis demonstrates that SRPK1 inhibition leads to altered isoform levels of many genes including several with established roles in leukemogenesis such as MYB, BRD4 and MED24. We focu...     »
Journal title abbreviation:
Nat Commun
Year:
2018
Journal volume:
9
Journal issue:
1
Pages contribution:
5378
Fulltext / DOI:
doi:10.1038/s41467-018-07620-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30568163
Print-ISSN:
2041-1723
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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