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Title:

Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG24-DFO[89Zr] for Tumor-Specific PET/CT Imaging.

Document type:
Journal Article
Author(s):
Stangl, Stefan; Tei, Lorenzo; De Rose, Francesco; Reder, Sybille; Martinelli, Jonathan; Sievert, Wolfgang; Shevtsov, Maxim; Öllinger, Rupert; Rad, Roland; Schwaiger, Markus; D'Alessandria, Calogero; Multhoff, Gabriele
Abstract:
High precision in vivo PET/CT imaging of solid tumors improves diagnostic credibility and clinical outcome of patients. An epitope of the oligomerization domain of Hsp70 is exclusively exposed on the membrane of a large variety of tumor types, but not on normal cells, and thus provides a universal tumor-specific target. Here we developed a novel PET tracer TPP-PEG24-DFO[89Zr] based on the tumor cell-penetrating peptide probe TPP, which specifically recognizes membrane Hsp70 (mHsp70) on tumor cel...     »
Journal title abbreviation:
Cancer Res
Year:
2018
Journal volume:
78
Journal issue:
21
Pages contribution:
6268-6281
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-18-0707
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30228173
Print-ISSN:
0008-5472
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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