Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, M S; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D; Dudek, Monika; Robson, Samuel C; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A; Ponstingl, Hannes; Dias, Joao M L; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew J; Rad, Roland; Prinjha, Rab K; Marioni, John C; Huntly, Brian; Batson, Jennife...     »
Abstract:
We recently identified the splicing kinase gene SRPK1 as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell differentiation and prolonged survival of mice transplanted with MLL-rearranged AML. RNA-seq analysis demonstrates that SRPK1 inhibition leads to altered isoform levels of many genes including several with established roles in leukemogenesis such as MYB, BRD4 and MED24. We focu...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2018
Band / Volume:
9
Heft / Issue:
1
Seitenangaben Beitrag:
5378
Volltext / DOI:
doi:10.1038/s41467-018-07620-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30568163
Print-ISSN:
2041-1723
TUM Einrichtung:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
 BibTeX