User: Guest  Login
Title:

STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury.

Document type:
Article; Journal Article
Author(s):
Kemmner, Stephan; Bachmann, Quirin; Steiger, Stefanie; Lorenz, Georg; Honarpisheh, Mohsen; Foresto-Neto, Orestes; Wang, Shijun; Carbajo-Lozoya, Javier; Alt, Verena; Schulte, Christian; Chmielewski, Stefan; Bluyssen, Hans A R; Heemann, Uwe; Baumann, Marcus; Lech, Maciej; Schmaderer, Christoph
Abstract:
Renal ischemia-reperfusion injury (IRI) leads to acute kidney injury or delayed allograft function, which predisposes to fibrosis in the native kidney or kidney transplant. Here we investigated the role of the signal transducer and activator of transcription 1 (STAT1) in inflammatory responses following renal IRI. Our study showed that a subsequent stimulation of Janus-activated kinase 2/STAT1 and Toll-like receptor 4 pathways led to greater STAT1 activation followed by increased cytokine transc...     »
Journal title abbreviation:
Am J Physiol Renal Physiol
Year:
2019
Journal volume:
316
Journal issue:
2
Pages contribution:
F277-F291
Fulltext / DOI:
doi:10.1152/ajprenal.00004.2018
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30403164
Print-ISSN:
1931-857X
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
 BibTeX