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Titel:

Enhanced Safety and Efficacy of Oncolytic VSV Therapy by Combination with T Cell Receptor Transgenic T Cells as Carriers.

Dokumenttyp:
Journal Article
Autor(en):
Melzer, Michael Karl; Zeitlinger, Lisa; Mall, Sabine; Steiger, Katja; Schmid, Roland M; Ebert, Oliver; Krackhardt, Angela; Altomonte, Jennifer
Abstract:
Vesicular stomatitis virus (VSV) represents an attractive oncolytic virotherapy platform because of its potent tumor cell-killing and immune-stimulating properties; yet the clinical translation of VSV faces numerous challenges, such as inefficient systemic delivery and severe side effects such as neurotoxicity. We hypothesized that we could overcome these limitations and simultaneously enhance the therapy, by combining VSV with adoptively transferred T cell receptor (TCR) transgenic T cells as...     »
Zeitschriftentitel:
Mol Ther Oncolytics
Jahr:
2019
Band / Volume:
12
Seitenangaben Beitrag:
26-40
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.omto.2018.12.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30662938
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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