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Titel:

HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1.

Dokumenttyp:
Article; Journal Article
Autor(en):
Beyer, Mandy; Romanski, Annette; Mustafa, Al-Hassan M; Pons, Miriam; Büchler, Iris; Vogel, Anja; Pautz, Andrea; Sellmer, Andreas; Schneider, Günter; Bug, Gesine; Krämer, Oliver H
Abstract:
Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AML cells were screened for viability, replication stress/DNA damage, and regrowth capacities after single exposures to the clinically used pan-HDACi panobinostat (LBH589), the class I HDACi entinostat/...     »
Zeitschriftentitel:
Cancers (Basel)
Jahr:
2019
Band / Volume:
11
Heft / Issue:
10
Volltext / DOI:
doi:10.3390/cancers11101436
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31561534
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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