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Title:

HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1.

Document type:
Article; Journal Article
Author(s):
Beyer, Mandy; Romanski, Annette; Mustafa, Al-Hassan M; Pons, Miriam; Büchler, Iris; Vogel, Anja; Pautz, Andrea; Sellmer, Andreas; Schneider, Günter; Bug, Gesine; Krämer, Oliver H
Abstract:
Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AML cells were screened for viability, replication stress/DNA damage, and regrowth capacities after single exposures to the clinically used pan-HDACi panobinostat (LBH589), the class I HDACi entinostat/...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2019
Journal volume:
11
Journal issue:
10
Fulltext / DOI:
doi:10.3390/cancers11101436
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31561534
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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