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Title:

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf mouse model.

Document type:
Journal Article; 12
Author(s):
Chapeau, Emilie A; Gembarska, Agnieszka; Durand, Eric Y; Mandon, Emeline; Estadieu, Claire; Romanet, Vincent; Wiesmann, Marion; Tiedt, Ralph; Lehar, Joseph; de Weck, Antoine; Rad, Roland; Barys, Louise; Jeay, Sebastien; Ferretti, Stephane; Kauffmann, Audrey; Sutter, Esther; Grevot, Armelle; Moulin, Pierre; Murakami, Masato; Sellers, William R; Hofmann, Francesco; Jensen, Michael Rugaard
Abstract:
Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent deletion in human cancer that, through inactivation of , activates MDM2 protein, which in turn degrades TP53 tumor suppressor. Here we used piggyBac (PB) transposon insertional mutagenesis to anticipate resistance mechanisms occurring during treatment with...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2017
Journal volume:
114
Journal issue:
12
Pages contribution:
3151-3156
Fulltext / DOI:
doi:10.1073/pnas.1620262114
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28265066
Print-ISSN:
0027-8424
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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