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Titel:

CXCR3 and Cognate Ligands are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Cannon, Andrew; Thompson, Christopher M; Maurer, H Carlo; Atri, Pranita; Bhatia, Rakesh; West, Sean; Ghersi, Dario; Olive, Kenneth P; Kumar, Sushil; Batra, Surinder K
Abstract:
PURPOSE: The cytokine milieu in pancreatic ductal adenocarcinoma (PDAC) promotes tumor progression and immune suppression, contributing to the dismal prognosis of patients with PDAC. The roles of many of these cytokines, however, have not been thoroughly investigated in PDAC. EXPERIMENTAL DESIGN: PDAC microarray and The Cancer Genome Atlas datasets were analyzed to identify cytokines and cognate receptors overexpressed in PDAC and associated with survival. Pathway and CIBERSORT analyses were use...     »
Zeitschriftentitel:
Clin Cancer Res
Jahr:
2020
Band / Volume:
26
Heft / Issue:
22
Seitenangaben Beitrag:
6051-6063
Volltext / DOI:
doi:10.1158/1078-0432.CCR-20-1359
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32873571
Print-ISSN:
1078-0432
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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