Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.

Dokumenttyp:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Dzulko, Melanie; Pons, Miriam; Henke, Andreas; Schneider, Günter; Krämer, Oliver H
Abstract:
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell proliferation, and DNA repair. Remarkably, PP2A can act as a context-dependent tumor suppressor or promoter. Active PP2A complexes consist of structural (PP2A-A), regulatory (PP2A-B), and catalytic (PP2A-C) subunits. The regulatory subunits define the substrate specificity and the subcellular localization of the holoenzyme. Here...     »
Zeitschriftentitel:
BBA - REVIEWS ON CANCER
Jahr:
2020
Band / Volume:
1874
Heft / Issue:
2
Volltext / DOI:
doi:10.1016/j.bbcan.2020.188453
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33068647
Print-ISSN:
0304-419X
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
 BibTeX