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Titel:

Magnetic Drug Targeting as New Therapeutic Option for the Treatment of Biomaterial Infections.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Obermeier, A; Küchler, S; Matl, FD; Pirzer, T; Stemberger, A; Mykhaylyk, O; Friess, W; Burgkart, R
Abstract:
Implant-associated infections are a challenging problem in surgery. Bacteria in biofilms are difficult to treat as they are less susceptible to antibiotics or antiseptics which require high drug concentrations at the site of infection. We present a novel strategy to concentrate high antibiotic doses systemically at the target site using newly developed antibiotic-functionalized nanoparticles directed by a magnetic drug-targeting system. The important and effective antibiotic gentamicin served as...     »
Zeitschriftentitel:
J Biomater Sci Polym Ed
Jahr:
2012
Band / Volume:
23
Heft / Issue:
18
Seitenangaben Beitrag:
2321-36
Sprache:
eng
Volltext / DOI:
doi:10.1163/156856211X616183
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22182398
Print-ISSN:
0920-5063
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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