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Title:

Functional investigation of the coronary artery disease gene SVEP1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Winkler, Michael J; Müller, Philipp; Sharifi, Amin M; Wobst, Jana; Winter, Hanna; Mokry, Michal; Ma, Lijiang; van der Laan, Sander W; Pang, Shichao; Miritsch, Benedikt; Hinterdobler, Julia; Werner, Julia; Stiller, Barbara; Güldener, Ulrich; Webb, Tom R; Asselbergs, Folkert W; Björkegren, Johan L M; Maegdefessel, Lars; Schunkert, Heribert; Sager, Hendrik B; Kessler, Thorsten
Abstract:
A missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) and vascular smooth muscle cells to represent the major cellular source of SVEP1 in plaques. Plaques were larger in atherosclerosis-prone Svep1 haploinsufficient (ApoE-/-Svep1+/-) compared to Svep1 wild-type mice (Apo...     »
Journal title abbreviation:
Basic Res Cardiol
Year:
2020
Journal volume:
115
Journal issue:
6
Fulltext / DOI:
doi:10.1007/s00395-020-00828-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33185739
Print-ISSN:
0300-8428
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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