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Title:

A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rakipovski, Günaj; Rolin, Bidda; Barascuk, Natasha; Lund, Heidi Engslev; Bjørn Bonde, Mathilde Frederikke; Djordjevic, Djordje; Wulff-Larsen, Pernille Gry; Petersen, Maj; Kirk, Rikke Kaae; Hultman, Karin; Manfe, Valentina; Blume, Niels; Zahn, Stefan; Lengquist, Mariette; Maegdefessel, Lars; Hovingh, G Kees; Conde-Knape, Karin; Hedin, Ulf; Matic, Ljubica; Nyberg, Michael
Abstract:
BACKGROUND AND AIMS: Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular pathophysiology but its involvement in atherosclerosis development and its therapeutic attractiveness remain to be established. METHODS: Patient data, in vitro studies and pharmacological intervention in murine models of atherosclerosis were utilized. R...     »
Journal title abbreviation:
Atherosclerosis
Year:
2020
Journal volume:
314
Pages contribution:
1-9
Fulltext / DOI:
doi:10.1016/j.atherosclerosis.2020.10.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33129080
Print-ISSN:
0021-9150
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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