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Title:

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.

Document type:
Article; Journal Article
Author(s):
Hinkel, Rabea; Ramanujam, Deepak; Kaczmarek, Veronika; Howe, Andrea; Klett, Katharina; Beck, Christina; Dueck, Anne; Thum, Thomas; Laugwitz, Karl-Ludwig; Maegdefessel, Lars; Weber, Christian; Kupatt, Christian; Engelhardt, Stefan
Abstract:
BACKGROUND: miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-animal models has been shown to be an effective antifibrotic strategy in various organs, including the heart. Effective delivery of therapeutic antisense micro-ribonucleic acid (antimiR) molecules to the myocardium in larger organisms is challenging, though, and remains to be established for models of chronic heart failure. OBJECTIVES: The aims of this study were to test the applicability and therapeutic e...     »
Journal title abbreviation:
J Am Coll Cardiol
Year:
2020
Journal volume:
75
Journal issue:
15
Pages contribution:
1788-1800
Fulltext / DOI:
doi:10.1016/j.jacc.2020.02.041
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32299591
Print-ISSN:
0735-1097
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Institut für Pharmakologie und Toxikologie; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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