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Titel:

Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide.

Dokumenttyp:
Journal Article
Autor(en):
Reichart, Florian; Maltsev, Oleg V; Kapp, Tobias G; Räder, Andreas F B; Weinmüller, Michael; Marelli, Udaya Kiran; Notni, Johannes; Wurzer, Alexander; Beck, Roswitha; Wester, Hans-Jürgen; Steiger, Katja; Di Maro, Salvatore; Di Leva, Francesco Saverio; Marinelli, Luciana; Nieberler, Markus; Reuning, Ute; Schwaiger, Markus; Kessler, Horst
Abstract:
Integrins play important roles in physiological and pathophysiological processes. Among the RGD-recognizing integrin subtypes, the αvβ8 receptor is emerging as an attractive target because of its involvement in various illnesses, such as autoimmune diseases, viral infections, and cancer. However, its functions have, so far, not been investigated in living subjects mainly because of the lack of a selective αvβ8 ligand. Here, we report the design and potential medical applications of a cyclic octa...     »
Zeitschriftentitel:
J Med Chem
Jahr:
2019
Band / Volume:
62
Heft / Issue:
4
Seitenangaben Beitrag:
2024-2037
Sprache:
eng
Volltext / DOI:
doi:10.1021/acs.jmedchem.8b01588
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30657681
Print-ISSN:
0022-2623
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Klinik und Poliklinik für Nuklearmedizin
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