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Title:

Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Silva, Lakmali Munasinghage; Kryza, Thomas; Stoll, Thomas; Hoogland, Christine; Dong, Ying; Stephens, Carson Ryan; Hastie, Marcus Lachlan; Magdolen, Viktor; Kleifeld, Oded; Gorman, Jeffrey John; Clements, Judith Ann
Abstract:
Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over expressed in ovarian cancer. In vitro functional analyses have suggested KLK7 to play a cancer progressive role, although monitoring of KLK7 expression has suggested a contradictory protective role for KLK7 in ovarian cancer patients. In order to help delineate its mechanism of action and thereby the functional roles, information on its substrate repertoire is crucial. Therefore, in this study a quantitative proteomics appr...     »
Journal title abbreviation:
Mol Cell Proteomics
Year:
2019
Journal volume:
18
Journal issue:
5
Pages contribution:
818-836
Fulltext / DOI:
doi:10.1074/mcp.RA118.001304
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30705123
Print-ISSN:
1535-9476
TUM Institution:
Frauenklinik und Poliklinik
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