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Titel:

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Dokumenttyp:
Journal Article; Article
Autor(en):
Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Mar...     »
Abstract:
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat obesity and the associated immunometabolic complications. Glucocorticoids are routinely employed for the management of inflammatory diseases, but their pleiotropic nature leads to detrimental metabolic side effects. We developed a glucagon-like peptide-1 (GLP-1)-dexamethasone co-agonist in which GLP-1 selectively delivers dexamethasone to GL...     »
Zeitschriftentitel:
Cell Metab
Jahr:
2017
Band / Volume:
26
Heft / Issue:
4
Seitenangaben Beitrag:
620-632.e6
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cmet.2017.08.023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28943448
Print-ISSN:
1550-4131
TUM Einrichtung:
Institut für Humangenetik; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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