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Title:

T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Dashtsoodol, Nyambayar; Bortoluzzi, Sabrina; Schmidt-Supprian, Marc
Abstract:
The CD1d-restricted Vα14 invariant NKT (iNKT) cell lineage in mice (Vα24 in humans) represents an evolutionary conserved innate-like immune cell type that recognizes glycolipid antigens. Because of their unique ability to promptly secrete copious amounts of both pro-inflammatory and anti-inflammatory cytokines, typically produced by different T helper cell types, iNKT cells are implicated in the regulation of various pathologic conditions such as infection, allergy, autoimmune disease, maintenan...     »
Journal title abbreviation:
Front Immunol
Year:
2019
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fimmu.2019.00841
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31080448
Print-ISSN:
1664-3224
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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