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Titel:

Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sellmayr, Markus; Hernandez Petzsche, Moritz Roman; Ma, Qiuyue; Krüger, Nils; Liapis, Helen; Brink, Andreas; Lenz, Barbara; Angelotti, Maria Lucia; Gnemmi, Viviane; Kuppe, Christoph; Kim, Hyojin; Bindels, Eric Moniqué Johannes; Tajti, Ferenc; Saez-Rodriguez, Julio; Lech, Maciej; Kramann, Rafael; Romagnani, Paola; Anders, Hans-Joachim; Steiger, Stefanie
Abstract:
BACKGROUND: The roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD progression are unknown. Hypotheses to explain links between UA deposition and progression of CKD include that (1) asymptomatic hyperuricemia does not promote CKD progression unless UA crystallizes in the kidney; (2) UA crystal granulomas may form due to pre-existing CKD; and (3) proinflammatory granuloma-related M1-like macrophages may drive UA crystal-induced CKD progression. METHODS: MALDI-FTICR mass spect...     »
Zeitschriftentitel:
J Am Soc Nephrol
Jahr:
2020
Band / Volume:
31
Heft / Issue:
12
Seitenangaben Beitrag:
2773-2792
Volltext / DOI:
doi:10.1681/ASN.2020040523
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32938648
Print-ISSN:
1046-6673
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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