The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2–Results from a prospective cohort of outpatient COVID-19 cases
Document type:
Zeitschriftenaufsatz
Author(s):
K. Puchinger; N. Castelletti; R. Rubio-Acero; C. Geldmacher; T. M. Eser; F. Deák; I. Paunovic; A. Bakuli; E. Saathoff; A. von Meyer; A. Markgraf; P. Falk; J. Reich; F. Riess; P. Girl; K. Müller; K. Radon; J. M. Guggenbuehl Noller; R. Wölfel; M. Hoelscher; I. Kroidl; A. Wieser; L. Olbrich; KoCo19 study group (M. Laxy)
Abstract:
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.
«
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to...
»
Keywords:
SARS-CoV-2 COVID-19 RT-PCR Viral culture Immune response Serological testing Public health