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Title:

RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Burgler, S; Mantel, PY; Bassin, C; Ouaked, N; Akdis, CA; Schmidt-Weber, CB
Abstract:
The process of Th cell differentiation toward polarized effector T cells tailors specific immunity against invading pathogens while allowing tolerance against commensal microorganisms, harmless allergens, or autologous Ags. Identification of the mechanisms underlying this polarization process is therefore central to understand how the immune system confers immunity and tolerance. The present study demonstrates that retinoic acid receptor-related orphan receptor C2 (RORC2), a key transcription fa...     »
Journal title abbreviation:
J Immunol
Year:
2010
Journal volume:
184
Journal issue:
11
Pages contribution:
6161-9
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.0903243
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20427770
Print-ISSN:
0022-1767
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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