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Titel:

The effects of acute loading on T1rho and T2 relaxation times of tibiofemoral articular cartilage.

Dokumenttyp:
journal article
Autor(en):
Souza, RB; Stehling, C; Wyman, BT; Hellio Le Graverand, MP; Li, X; Link, TM; Majumdar, S
Abstract:
To evaluate the effect of acute loading on healthy and osteoarthritic knee cartilage T(1?) and T(2) relaxation times.Twenty subjects with radiographic evidence of osteoarthritis (OA) and 10 age-matched controls were enrolled. Magnetic resonance imaging (MRI) acquisition, including T(1?) and T(2) map sequences were performed unloaded and loaded at 50% body mass. Cartilage masks were segmented semi-automatically on registered high-resolution spoiled gradient-echo (SPGR) images for each compartment (medial and lateral). Cartilage lesions were identified using a modified Whole Organ Magnetic Resonance Imaging Score (WORMS) score. Statistical differences were explored using separate two-way (group×loading condition) Analysis of Variance (ANOVA) using age as a covariate to evaluate the effects of loading on T(1?) and T(2) relaxation times.A significant decrease in T(1?) (44.5±3.8 vs 40.2±4.8ms for unloaded and loaded, respectively; P<0.001) and T(2) (31.8±3.8 vs 30.5±4.8ms for unloaded and loaded, respectively; P<0.001) relaxation times was observed in the medial compartment with loading while no differences were observed in the lateral compartment. This behavior occurred independent of WORMS score. Cartilage compartments with small focal lesions experienced greater T(1?) change scores with loading when compared to cartilage without lesions or cartilage with larger defects (P=0.05).Acute loading resulted in a significant decrease in T(1?) and T(2) relaxation times of the medial compartment, with greater change scores observed in cartilage regions with small focal lesions. These data suggest that changes of T(1?) values with loading may be related to cartilage biomechanical properties (i.e., tissue elasticity) and may be a valuable tool for the scientist and clinician at identifying early cartilage disease.
Zeitschriftentitel:
Osteoarthritis Cartilage
Jahr:
2010
Band / Volume:
18
Heft / Issue:
12
Seitenangaben Beitrag:
1557-63
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20950693
Print-ISSN:
1063-4584
TUM Einrichtung:
Röntgendiagnostik
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