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Title:

Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Chen, X; Kovalchuk, Y; Adelsberger, H; Henning, HA; Sausbier, M; Wietzorrek, G; Ruth, P; Yarom, Y; Konnerth, A
Abstract:
The large-conductance voltage- and calcium-activated potassium (BK) channels are ubiquitously expressed in the brain and play an important role in the regulation of neuronal excitation. Previous work has shown that the total deletion of these channels causes an impaired motor behavior, consistent with a cerebellar dysfunction. Cellular analyses showed that a decrease in spike firing rate occurred in at least two types of cerebellar neurons, namely in Purkinje neurons (PNs) and in Golgi cells. To...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2010
Journal volume:
107
Journal issue:
27
Pages contribution:
12323-8
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1001745107
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20566869
Print-ISSN:
0027-8424
TUM Institution:
Institut für Neurowissenschaften
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