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Titel:

Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Leitner, L; Shaposhnikov, D; Descot, A; Hoffmann, R; Posern, G
Abstract:
Epithelial Protein Lost in Neoplasm alpha is a novel cytoskeleton-associated tumor suppressor whose expression inversely correlates with cell growth, motility, invasion and cancer mortality. Here we show that Eplin-alpha transcription is regulated by actin-MAL-SRF signalling. Upon signal induction, the coactivator MAL/MRTF is released from a repressive complex with monomeric actin, binds the transcription factor SRF and activates target gene expression. In a transcriptome analysis with a combina...     »
Zeitschriftentitel:
Mol Cancer
Jahr:
2010
Band / Volume:
9
Seitenangaben Beitrag:
60
Sprache:
eng
Volltext / DOI:
doi:10.1186/1476-4598-9-60
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20236507
Print-ISSN:
1476-4598
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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