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- Title:
Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist.
- Document type:
- Comment; Journal Article
- Author(s):
- Wagner, H
- Abstract:
- The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
- Journal title abbreviation:
- Cell Host Microbe
- Year:
- 2010
- Journal volume:
- 7
- Journal issue:
- 1
- Pages contribution:
- 5-6
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.chom.2010.01.002
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/20114022
- Print-ISSN:
- 1931-3128
- TUM Institution:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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