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Titel:

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Hinterberger, M; Aichinger, M; da Costa, OP; Voehringer, D; Hoffmann, R; Klein, L
Abstract:
Medullary thymic epithelial cells (mTECs) serve an essential function in central tolerance by expressing peripheral-tissue antigens. These antigens may be transferred to and presented by dendritic cells (DCs). Therefore, it is unclear whether mTECs, in addition to being an antigen reservoir, also serve a mandatory function as antigen-presenting cells. Here we diminished major histocompatibility complex (MHC) class II on mTECs through transgenic expression of a 'designer' microRNA specific for th...     »
Zeitschriftentitel:
Nat Immunol
Jahr:
2010
Band / Volume:
11
Heft / Issue:
6
Seitenangaben Beitrag:
512-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/ni.1874
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20431619
Print-ISSN:
1529-2908
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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