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Titel:

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
Voight, BF; Scott, LJ; Steinthorsdottir, V; Morris, AP; Dina, C; Welch, RP; Zeggini, E; Huth, C; Aulchenko, YS; Thorleifsson, G; Mcculloch, LJ; Ferreira, T; Grallert, H; Amin, N; Wu, G; Willer, CJ; Raychaudhuri, S; Mccarroll, SA; Langenberg, C; Hofmann, OM; Dupuis, J; Qi, L; Segrè, AV; van Hoek, M; Navarro, P; Ardlie, K; Balkau, B; Benediktsson, R; Bennett, AJ; Blagieva, R; Boerwinkle, E; Bonnycastle, LL; Bengtsson Boström, K; Bravenboer, B; Bumpstead, S; Burtt, NP; Charpentier, G; Chines, PS; C...     »
Abstract:
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
Zeitschriftentitel:
Nat Genet
Jahr:
2010
Band / Volume:
42
Heft / Issue:
7
Seitenangaben Beitrag:
579-89
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.609
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20581827
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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