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Title:

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lattka, E; Eggers, S; Moeller, G; Heim, K; Weber, M; Mehta, D; Prokisch, H; Illig, T; Adamski, J
Abstract:
Fatty acid desaturases (FADS) play an important role in the formation of omega-6 and omega-3 highly unsaturated fatty acids (HUFAs). The composition of HUFAs in the human metabolome is important for membrane fluidity and for the modulation of essential physiological functions such as inflammation processes and brain development. Several recent studies reported significant associations of single nucleotide polymorphisms (SNPs) in the human FADS gene cluster with HUFA levels and composition. The p...     »
Journal title abbreviation:
J Lipid Res
Year:
2010
Journal volume:
51
Journal issue:
1
Pages contribution:
182-91
Language:
eng
Fulltext / DOI:
doi:10.1194/jlr.M900289-JLR200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19546342
Print-ISSN:
0022-2275
TUM Institution:
Institut für Humangenetik
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