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Titel:

Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
Hemminki, K; Müller-Myhsok, B; Lichtner, P; Engel, C; Chen, B; Burwinkel, B; Försti, A; Sutter, C; Wappenschmidt, B; Hellebrand, H; Illig, T; Arnold, N; Niederacher, D; Dworniczak, B; Deissler, H; Kast, K; Gadzicki, D; Meitinger, T; Wichmann, HE; Kiechle, M; Bartram, CR; Schmutzler, RK; Meindl, A
Abstract:
To validate common low-risk variants predisposing for breast cancer (BC) in a large set of BRCA1/2 negative familial or genetically enriched cases from Germany, we genotyped 1,415 cases and 1,830 healthy women by MALDI-TOF in 105 candidate SNPs. Significantly higher ORs than previously reported for heterozygous unselected cases were found for the minor allele in FGFR2 (OR = 1.43, 95% CI 1.30-1.59, p-value = 1.24 x 10(-12)) and for TNRC9 (OR = 1.33, 95% CI 1.19-1.46, p-value = 1.54 x 10(-7)). Mos...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2010
Band / Volume:
126
Heft / Issue:
12
Seitenangaben Beitrag:
2858-62
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.24986
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19856316
Print-ISSN:
0020-7136
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Humangenetik
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