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Title:

Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Beyerle, A; Braun, A; Merkel, O; Koch, F; Kissel, T; Stoeger, T
Abstract:
Pulmonary siRNA delivery offers a new way to treat various lung diseases. Poly(ethylene imines) (PEIs) are promising cationic nanocarriers and various modifications are still under investigations to improve their cytotoxicity and efficacy for siRNA delivery. In this study, we analyzed two different types of PEI-based nanocomplexes in mice after intratracheal administration regarding their toxicity and efficacy in the lungs. Ubiquitously enhanced green fluorescent protein (EGFP) expressing transg...     »
Journal title abbreviation:
J Control Release
Year:
2011
Journal volume:
151
Journal issue:
1
Pages contribution:
51-6
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jconrel.2010.12.017
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21223987
Print-ISSN:
0168-3659
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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