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Title:

IL-22 and TNF-? represent a key cytokine combination for epidermal integrity during infection with Candida albicans.

Document type:
Journal Article; Article
Author(s):
Eyerich, S; Wagener, J; Wenzel, V; Scarponi, C; Pennino, D; Albanesi, C; Schaller, M; Behrendt, H; Ring, J; Schmidt-Weber, CB; Cavani, A; Mempel, M; Traidl-Hoffmann, C; Eyerich, K
Abstract:
T cells exercise their full impact on target cells through a combination of secreted cytokines. The recently described T helper cell subset Th22 is characterized by a combinatorial secretion of IL-22 and TNF-?. Here, we demonstrate that IL-22 increases the TNF-?-dependent induction and secretion of several immune-modulatory molecules such as initial complement factors C1r and C1s, antimicrobial peptides S100A7 and HBD-2 (human ? defensin 2), and antimicrobial chemokines CXCL-9/-10/-11 in primary...     »
Journal title abbreviation:
Eur J Immunol
Year:
2011
Journal volume:
41
Journal issue:
7
Pages contribution:
1894-901
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201041197
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21469124
Print-ISSN:
0014-2980
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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