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Titel:

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hoegen, T; Tremel, N; Klein, M; Angele, B; Wagner, H; Kirschning, C; Pfister, HW; Fontana, A; Hammerschmidt, S; Koedel, U
Abstract:
Streptococcus pneumoniae meningitis causes brain damage through inflammation-related pathways whose identity and mechanisms of action are yet unclear. We previously identified caspase-1, which activates precursor IL-1 type cytokines, as a central mediator of inflammation in pneumococcal meningitis. In this study, we demonstrate that lack of the inflammasome components ASC or NLRP3 that are centrally involved in caspase-1 activation decreases scores of clinical and histological disease severity a...     »
Zeitschriftentitel:
J Immunol
Jahr:
2011
Band / Volume:
187
Heft / Issue:
10
Seitenangaben Beitrag:
5440-51
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1100790
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22003197
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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