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Titel:

CD8+ T cell differentiation in the aging immune system: until the last clone standing.

Dokumenttyp:
Journal Article; Review
Autor(en):
Buchholz, VR; Neuenhahn, M; Busch, DH
Abstract:
A substantial deterioration of the naïve CD8(+) T cell pool occurs regularly in humans beyond the age of 65 years. While recall responses to pathogens encountered during youth or adulthood are largely uncompromised, the de novo generation of memory responses by aged naïve CD8(+) T cells is perturbed. In recent years evidence has accumulated that the diminished responsiveness of naïve CD8(+) T cells in aged humans and other mammals coincides with a progressive loss of naïve T cell receptor (TCR)...     »
Zeitschriftentitel:
Curr Opin Immunol
Jahr:
2011
Band / Volume:
23
Heft / Issue:
4
Seitenangaben Beitrag:
549-54
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.coi.2011.05.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21664807
Print-ISSN:
0952-7915
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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