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Titel:

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Winkelmann, J; Czamara, D; Schormair, B; Knauf, F; Schulte, EC; Trenkwalder, C; Dauvilliers, Y; Polo, O; Högl, B; Berger, K; Fuhs, A; Gross, N; Stiasny-Kolster, K; Oertel, W; Bachmann, CG; Paulus, W; Xiong, L; Montplaisir, J; Rouleau, GA; Fietze, I; Vávrová, J; Kemlink, D; Sonka, K; Nevsimalova, S; Lin, SC; Wszolek, Z; Vilarino-Guell, C; Farrer, MJ; Gschliesser, V; Frauscher, B; Falkenstetter, T; Poewe, W; Allen, RP; Earley, CJ; Ondo, WG; Le, WD; Spieler, D; Kaffe, M; Zimprich, A; Kettunen, J; P...     »
Abstract:
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that occurs mainly in resting situations during the evening or at night. Moving the legs or walking leads to an improvement of symptoms. Concomitantly, patients report sleep disturbances with consequences such as reduced daytime functioning. We conduct...     »
Zeitschriftentitel:
PLoS Genet
Jahr:
2011
Band / Volume:
7
Heft / Issue:
7
Seitenangaben Beitrag:
e1002171
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pgen.1002171
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21779176
Print-ISSN:
1553-7390
TUM Einrichtung:
Institut für Humangenetik; Neurologische Klinik und Poliklinik
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