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Title:

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Document type:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Schunkert, H; König, IR; Kathiresan, S; Reilly, MP; Assimes, TL; Holm, H; Preuss, M; Stewart, AF; Barbalic, M; Gieger, C; Absher, D; Aherrahrou, Z; Allayee, H; Altshuler, D; Anand, SS; Andersen, K; Anderson, JL; Ardissino, D; Ball, SG; Balmforth, AJ; Barnes, TA; Becker, DM; Becker, LC; Berger, K; Bis, JC; Boekholdt, SM; Boerwinkle, E; Braund, PS; Brown, MJ; Burnett, MS; Buysschaert, I; Carlquist, JF; Chen, L; Cichon, S; Codd, V; Davies, RW; Dedoussis, G; Dehghan, A; Demissie, S; Devaney, JM; Die...     »
Abstract:
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10?? and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
Journal title abbreviation:
Nat Genet
Year:
2011
Journal volume:
43
Journal issue:
4
Pages contribution:
333-8
Language:
eng
Fulltext / DOI:
doi:10.1038/ng.784
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21378990
Print-ISSN:
1061-4036
TUM Institution:
Institut für Humangenetik
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