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Titel:

MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer.

Dokumenttyp:
Journal Article; Evaluation Studies
Autor(en):
Balluff, B; Rauser, S; Meding, S; Elsner, M; Schone, C; Feuchtinger, A; Schuhmacher, C; Novotny, A; Jütting, U; Maccarrone, G; Sarioglu, H; Ueffing, M; Braselmann, H; Zitzelsberger, H; Schmid, RM; Höfler, H; Ebert, MP; Walch, A
Abstract:
Proteomics-based approaches allow us to investigate the biology of cancer beyond genomic initiatives. We used histology-based matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry to identify proteins that predict disease outcome in gastric cancer after surgical resection. A total of 181 intestinal-type primary resected gastric cancer tissues from two independent patient cohorts were analyzed. Protein profiles of the discovery cohort (n = 63) were directly obtained from t...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2011
Band / Volume:
179
Heft / Issue:
6
Seitenangaben Beitrag:
2720-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ajpath.2011.08.032
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22015459
Print-ISSN:
0002-9440
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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