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Titel:

Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Halama, N; Michel, S; Kloor, M; Zoernig, I; Benner, A; Spille, A; Pommerencke, T; von Knebel, DM; Folprecht, G; Luber, B; Feyen, N; Martens, UM; Beckhove, P; Gnjatic, S; Schirmacher, P; Herpel, E; Weitz, J; Grabe, N; Jaeger, D
Abstract:
Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer (CRC) by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC. Specifically, high densities of TILs in the primary tumor are associated with good prognosis independent of other prognostic markers. However, the prognostic role of TILs in metastatic CRC lesions is unknown, as is their role in response or resistance to conventional chemothe...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2011
Band / Volume:
71
Heft / Issue:
17
Seitenangaben Beitrag:
5670-7
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-11-0268
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21846824
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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