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Title:

Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Diem, O; Schäffner, M; Seifarth, W; Leib-Mösch, C
Abstract:
Human endogenous retroviruses (HERVs) have been associated with various neurological and neuropsychiatric disorders. Transcripts and proteins of at least three HERV groups, HERV-W, ERV9 and HERV-K(HML-2) have been detected repeatedly in brain samples or cerebrospinal fluid of patients with schizophrenia suggesting that alterations in HERV activity may play a role in etiopathogenesis. Current therapies otherwise include neuroleptics and/or antidepressants that may induce epigenetic alterations an...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
1
Pages contribution:
e30054
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0030054
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22253875
Print-ISSN:
1932-6203
TUM Institution:
Institut für Virologie
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